Rybelsus (Oral Semaglutide)
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Available Options
3mg
30 tablets
7mg
30 tablets
14mg
30 tablets
Important Information
- • A valid prescription is required for all orders
- • Orders are shipped within 3–7 business days
- • Express shipping with cold chain packaging to keep your medication safe and effective
Description
Rybelsus is the first and only oral GLP-1 receptor agonist medication, containing semaglutide, approved for the treatment of Type 2 diabetes in adults. Unlike injectable GLP-1 therapies, Rybelsus is taken once daily by mouth and offers patients a needle-free option to improve blood sugar control.
Rybelsus mimics the action of the naturally occurring GLP-1 hormone. It works by stimulating insulin secretion when blood sugar is high, reducing glucagon secretion, and delaying gastric emptying. These mechanisms help regulate post-meal glucose levels and improve overall glycemic control. Rybelsus has also been associated with modest weight loss, making it beneficial for patients with Type 2 diabetes who are overweight.
Rybelsus is not recommended as first-line therapy and should be used in combination with lifestyle changes such as diet and exercise. It is not approved for use in people with Type 1 diabetes or diabetic ketoacidosis.
Fact Table
| Formula | C187H291N45O59 |
|---|---|
| License | EU EMA, US FDA |
| Chemical Name | Semaglutide |
| Dosage (Strength) |
|
| Route | Oral (by mouth, tablet form) |
| Bioavailability | ~0.4% |
Directions
- Take Rybelsus once daily on an empty stomach with no more than 4 ounces of water.
- Do not eat, drink, or take other oral medications for at least 30 minutes after taking the tablet.
- Take it at the same time each day. Do not crush, cut, or chew the tablet.
Ingredients
The active ingredient in Rybelsus is Semaglutide, formulated as an oral tablet using absorption-enhancing technology.
Cautions
- Do not use Rybelsus if you or any family member has a history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Avoid use if allergic to semaglutide or any component of the tablet.
- Monitor for signs of pancreatitis, kidney issues, or diabetic retinopathy complications.
- Store tablets in the original blister pack at room temperature (68–77°F / 20–25°C) in a dry place, protected from moisture.
Interactions
Rybelsus may delay gastric emptying and interfere with the absorption of other oral medications. Always inform your healthcare provider of all medications, supplements, or herbal products before starting Rybelsus.
Side Effects
- Common: nausea, vomiting, diarrhea, stomach pain, and decreased appetite.
- Rare but serious: pancreatitis, kidney impairment, and possible thyroid tumors. Contact your doctor if severe symptoms occur.
Frequently Asked Questions
What is Rybelsus used for?
Rybelsus is prescribed to adults with Type 2 diabetes to improve blood sugar control when used along with diet and exercise.
How does Rybelsus work?
Rybelsus activates GLP-1 receptors to enhance insulin secretion, lower glucagon, and delay stomach emptying, helping regulate blood glucose.
Is Rybelsus the same as Ozempic?
Both contain semaglutide, but Rybelsus is taken orally once a day, while Ozempic is an injectable used once a week.
Can Rybelsus help with weight loss?
Yes, many patients experience weight loss as a secondary benefit, especially at higher doses like 14mg.
How fast does Rybelsus start working?
Initial blood sugar improvements can be seen within a few weeks, with full effects typically after 8–12 weeks.
Can Rybelsus be taken with other diabetes medications?
Yes, but combinations should be managed by your doctor to avoid risks of low blood sugar.
What are the side effects of Rybelsus?
Common effects include nausea, diarrhea, and reduced appetite. Serious side effects may include pancreatitis or thyroid issues.
Is Rybelsus approved internationally?
Yes, Rybelsus is approved by the FDA in the U.S. and the EMA in Europe for use in Type 2 diabetes.
Do I need to refrigerate Rybelsus?
No, Rybelsus should be stored at room temperature in its original blister packaging, away from moisture.
Is Rybelsus suitable for people who fear needles?
Yes, Rybelsus is the only oral GLP-1 receptor agonist available, offering a needle-free option for diabetes management.
Important Note
The information above is provided for educational purposes only and should not replace professional medical advice. Please consult a qualified healthcare provider for personalized guidance on medication safety, suitability, and proper use.